A case report on “Ameloblastic carcinoma: A secondary aggressive odontogenic neoplasm”


  • Karthika Borra Private practitioner at Yousuf Guda area, Hyderabad
  • Rakashree Chakraborty Lecturer, MM College of Dental Sciences & Research
  • Ashmita Chawla PG Scholor (3 year), Department of Oral Medicine and Radiology, Sri Aurobindo College of Dentistry, Indore, Madhyapradesh Medical Science University (MPMSU)
  • Aditya Dupare Senior Lecturer, Department of Oral Medicine and Radiology, Yogita Dental College and Hospital, Khed, Maharashtra University of Health Science, Nashik




Ameloblastic carcinoma, odontogenic tumor, pre-existing ameloblastoma, pre-existing benign odontogenic cyst, malignant ameloblastoma


Ameloblastic carcinoma is a rare aggressive odontogenic neoplasm which was initially an ameloblastoma or an odontogenic cyst and then undergone malignant transformation. Ameloblastic carcinoma accounts for 2% of all the odontogenic tumors. Identifying a secondary type of Ameloblastic carcinoma with typical histologic features of malignant transformation is difficult to diagnose and remains a rarity. Here we report a case of a male patient of age 85 years with typical clinical findings for ameloblastomic carcinoma with its typical clinical and histopathological features and it’s surgical procedure. This case resembles squamous cell carcinoma of alveolus and osteomyelitis. The diagnosis is based on the detailed history of the patient followed by the clinical findings and suitable radiographs and finally the microscopic evaluation. Wide surgical excision with adjunctive radiation is the treatment of choice. The risk of recurrence is very high and prognosis remains poor


Jing W, Xuan M,Lin Y et al. Odontogenic tumors: A retrospective study of 1642 cases in a Chinese population. Int J Oral Maxillofac Surg 2007;36:20-5.

Ladeinde Al, Ajayi OF,Ogunlewe MO, et al. Odontogenic tumors: A review of 319 cases in a Nigerian teaching hospital. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99:191-5.

Sciubba JJ, Eversole LR, Slootweg PJ: Odontogenic/ameloblastic carcinomas. In: Barnes L, Eveson JW, Reichart P et al. (eds.), World Health Organization Classification of Tumours. Pathology and Genetics of Head and Neck Tumours. Lyon: IARC Press; 2005; 287–9.

Shafer W, Hine M, Levy B: A textbook of Oral Pathology. 4th ed. USA: WB Saunders, 1974.

Hall JM, Weathers DR, Unni KK: Ameloblastic carcinoma: an analysis of 14 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;103:799–807.

Akrish S, Buchner A, Shoshani Y et al: Ameloblastic carcinoma: report of a new case, literature review, and comparison to ameloblastoma. J Oral Maxillofac Surg 2007;65:777–83.

Karakida K, Aoki T, Sakamoto H et al: Ameloblastic carcinoma, secondary type: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2010;110:e33–7.

Yoon HJ, Hong SP, Lee JI et al: Ameloblastic carcinoma: an analysis of 6 cases with review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2009;108: 904–13.

CizmecýO,AslanA,OnelD,DemiryontM.Ameloblasticcarcinoma ex ameloblastoma of the mandible: case report. Otolaryngol Head Neck Surg. 2004;130:633-4.

Cordeiro PG, Disa JJ, Hidalgo DA, Hu QY. Reconstruction of the mandible with osseous free flaps: a 10-year experience with 150 consecutive patients. Plast Reconstr Surg. 1999;104(5):1314-20.

Philip M, Morris CG, Werning JW, Mendenhall WM. Radiotherapy in the Treatment of Ameloblastoma and Ameloblastic Carcinoma. J HK Coll Radiol 2005;8:157-61.

Ramadas K, Jose CC, Subhashini J, Chandi SM, Viswanathan FR. Pulmonary metastasis from ameloblastoma of the mandible treated with cisplatin, adriamycin and cyclophosphamide. Cancer 1990;66(7):1475-9.




How to Cite

Borra, K., Chakraborty, R., Chawla, A., & Dupare, A. (2021). A case report on “Ameloblastic carcinoma: A secondary aggressive odontogenic neoplasm”. UNIVERSITY JOURNAL MAXILLOFACIAL SURGERY AND ORAL SCIENCES, 1(2). https://doi.org/10.52977/ujmfs.2021.1.2.15